Effect of collagen-chitosan hydrogel formula combined with platelet-rich plasma (A study of ph, viscocity, and swelling test)

Platelet-rich plasma (PRP) contains growth factors that speed up a healing process. The liquid form of PRP is difficult to be applied, so it needs material as carrier collagen. Collagen can used materials and capable activate increase the concentration become gel. often losses its shape size due degradation when exposed body fluids. In selection materials, collagen synthesize with chitosan. Collagen-chitosan hydrogel has potential scaffold. Many formulations for proper applied in oral cavity need pay more attention several conditions, such neutral pH, high viscosity ideal swelling. aims this study was examine influence various collagenchitosan PRPagainst viscosity, samples consisted 25 collagen-chitosanhydrogel formulations. were divided into five groups: 100/0; 75/25; 50/50; 25/75; 0/100. first stage test swelling measurement collagen-chitosan determine which ones matched criteria. added ratio 1:1. second measure see results physical parameters after mixed PRP. observation data analyzed by t-test pH while twoway ANOVA post hoc LSD test. showed 25/75 0/100 met criteria both groups no significant difference (p>0.05), but variables (p<0.05). To conclude, had effect on an